Immunology Reagent

Immunology ELISA kits


Histamine is a biogenic amine synthesized from the amino acid histidine. It is an important mediator of many biological reactions in the body, notably of allergic and pseudoallergic reactions. Histamine is metabolized in the body via two different enzymes: First, by the secretory enzyme diamine oxidase (DAO) and second by the enzyme histamine-N-methyltransferase (HNMT). The two systems complement one another, since DAO is mainly responsible for regulation of extracellular histamine while HNMT is responsible for intracellular regulation in the cytosol. The histamine concentration in the body can be influenced by a variety of factors. Histamine is both produced in the body itself and taken up with food. In addition, certain foods can cause the release of histamine stored in the body.

Histamine intolerance is a clinical picture that has been observed with increasing frequency in recent years. The symptoms experienced by patients are gastrointestinal problems, diarrhoea, nausea, migraine-like headaches, skin reddening, pruritus, hot flushes, colds or similar symptoms such as limb pains or tiredness. The pathological basis of this condition is an imbalance between the amount of histamine present and histamine degradation by DAO. In patients with reduced activity of DAO, which is especially located in the intestine, increased amounts of Histamine are excreted with the stool. The Histamine Stool ELISA (BA E-1200) is an assay for the quantitative determination of histamine in stool.

Histamine is a naturally occurring biogenic amine which is found to various degrees in many foods. The Histamine concentrations depend on the maturation progress, the degree of freshness and the way food is processed. Foods with high histamine concentrations include: Alcoholic beverages (beer, champagne and wine), cheeses (especially aged or fermented cheese), dried fruits, fish and fish products, smoked meats, sauerkraut, processed meats such as sausage and salami, salad dressing, ketchup, and many more.


  Histamine Stool ELISA


  BA E-1200